Temperature Trajectory Sub-phenotypes and the Immuno-Inflammatory Response in Pediatric Sepsis

Conclusions: Critically ill septic children can be categorized into temperature trajectory-defined sub-phenotypes that parallel adult sepsis. Hypothermic children exhibit a blunted cytokine and chemokine profile. Group-based trajectory modeling has utility for identifying subtypes of clinical syndromes by incorporating readily available longitudinal data, rather than relying on inputs from a single timepoint.
Source: Shock - Category: Emergency Medicine Tags: Clinical Aspects (Human Subjects) Source Type: research