Efficacy of a carrageenan gel in preventing anal human papillomavirus (HPV) infection: interim analysis of the Lubricant Investigation in Men to Inhibit Transmission of HPV Infection (LIMIT-HPV) randomised controlled trial

Conclusions
The interim analysis did not demonstrate a protective effect of carrageenan on the risk of new detections of anal HPV infection among gbMSM. Carrageenan gel use was associated with a higher proportion of adverse events. Given these findings and the (assumed) low probability that a beneficial effect would be found by the study’s end, the trial was terminated as recommended by the Data Safety and Monitoring Board.

Trial registration number
NCT02354144.

Source: Sexually Transmitted Infections - May 17, 2022 Category: Sexual Medicine Authors: Laurie, C., El-Zein, M., Tota, J. E., Khosrow-Khavar, F., Tellier, P.-P., Coutlee, F., de Pokomandy, A., Franco, E. L., for the LIMIT-HPV study group, Rodrigues, Morykon, Rodrigues, Bouten, Shapiro, Tsyruk, Leblanc, Trottier, Castro, Proulx-Boucher, Theri Tags: Epidemiology Source Type: research