Vascular smooth muscle cell c-Fos is critical for foam cell formation and atherosclerosis

Hyperlipidemia-induced vascular smooth muscle cell (VSMC)-derived foam cell formation is considered a crucial event in the development of atherosclerosis. Since c-Fos emerges as a key modulator of lipid metabolism, we investigated whether c-Fos plays a role in hyperlipidemia-induced VSMC-derived foam cell formation and atherosclerosis.

Source: Metabolism - Clinical and Experimental - May 2, 2022 Category: Biomedical Science Authors: Guolin Miao, Xi Zhao, Siu-Lung Chan, Lijun Zhang, Yaohua Li, Yuke Zhang, Lijun Zhang, Beibei Wang Source Type: research