High Values of Drain Fluid Epidermal Growth Factor and Transforming Growth Factor-beta are Associated with the Development of Pancreatic Fistula after Pancreatoduodenectomy

Introduction
Postoperative inflammatory response may act as a major determinant of anastomotic failure after pancreaticoduodenectomy. In this pilot study, we investigated the potential role of drain fluid cytokines in predicting postoperative pancreatic fistula (POPF).
Methods
Drain fluid TGF- β, IGF-1, EGF and IL-6, together with serum amylase and drain fluid amylase were measured on POD1 and correlated to the development of POPF.
Results
The study population consisted of 66 patients. POPF and Clavien-Dindo 3 morbidity rates were 12.1% and 9.1%, respectively. Patients developing P OPF presented significantly higher values of POD1 serum amylase level (477 vs 54UI/L, p

Source: Digestive Surgery - April 25, 2022 Category: Surgery Source Type: research