DAMPs activating innate immune responses in sepsis.

DAMPs activating innate immune responses in sepsis.
Ageing Res Rev. 2015 Mar 25;
Authors: Kang JW, Kim SJ, Cho HI, Lee SM
Abstract
Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the host to microbial infection and is the leading cause of death in intensive care units. The pathogenesis of sepsis is highly complex. It is principally attributable to dysregulation of the innate immune system. Damage-associated molecular patterns (DAMPs) are actively secreted by innate immune cells and/or released passively by injured or damaged cells in response to infection or injury. In the present review, we highlight emerging evidence that supports the notion that extracellular DAMPs act as crucial proinflammatory danger signals. Furthermore, we discuss the potential of a wide array of DAMPs as therapeutic targets in sepsis.
PMID: 25816752 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - March 25, 2015 Category: Genetics & Stem Cells Authors: Kang JW, Kim SJ, Cho HI, Lee SM Tags: Ageing Res Rev Source Type: research