Structural studies of various olmesartan solvates

Seven solvates of the angiotensin II receptor blocker agent olmesartan (C24H26N6O3), namely, the methanol (C24H26N6O3 · CH4O), ethanol (C24H26N6O3 · C2H6O), isopropanol (C24H26N6O3 · C3H8O), isobutanol (C24H26N6O3 · C4H10O), 2-ethoxyethanol (C24H26N6O3 · C4H10O2), chloroform (C24H26N6O3 · CHCl3) and acetonitrile (C24H26N6O3 · C2H3N) solvates, were successfully obtained. The crystal structures were determined using the single-crystal X-ray diffraction technique and the structural features are described, each solvate containing one molecule of olmesartan and one of solvent in the asymmetric unit. The samples were also analyzed by powder X-ray diffraction. Total lattice energies and binding energies between the olmesartan and solvent molecules were evaluated, which can be partitioned into electrostatic, polarization, dispersion and repulsion components. Hirshfeld and fingerprint plot analysis was performed to highlight the intermolecular contacts. Hydrogen bonding and supramolecular arrangements were comparatively studied for the seven solvates.

Source: Acta Crystallographica Section C - March 25, 2022 Category: Chemistry Authors: Grosu, I.G. Martin, F. Turza, A. Miclaus, M. Kacso, I. Borodi, G. Tags: olmesartan isostructural solid form crystal structure angiotensin II receptor blocker agent research papers Source Type: research