α4-Integrin deficiency in human CD34+ cells engenders precocious erythroid differentiation but inhibits enucleation

The functional impact of integrin expression in erythropoiesis has been previously emphasized through its decisive influence on erythroid cell –microenvironment (matrix and cellular) interactions, especially under conditions of stress. Beyond that, in several in vitro studies the relationship between the two erythroid integrins, α4 and α5, has been incongruous in terms of a proliferative support, either synergistic or antagonistic, whe reas a dominant influence of α4 integrin on terminal erythropoiesis in vitro and in vivo has been consistently emphasized.

Source: Experimental Hematology - February 26, 2022 Category: Hematology Authors: Tatyana Ulyanova, Jennifer M. Cherone, Pavel Sova, Thalia Papayannopoulou Tags: Regular submission Source Type: research