Genes, Vol. 13, Pages 200: Rec8 Cohesin: A Structural Platform for Shaping the Meiotic Chromosomes

Genes, Vol. 13, Pages 200: Rec8 Cohesin: A Structural Platform for Shaping the Meiotic Chromosomes
Genes doi: 10.3390/genes13020200
Authors:
Takeshi Sakuno
Yasushi Hiraoka

Meiosis is critically different from mitosis in that during meiosis, pairing and segregation of homologous chromosomes occur. During meiosis, the morphology of sister chromatids changes drastically, forming a prominent axial structure in the synaptonemal complex. The meiosis-specific cohesin complex plays a central role in the regulation of the processes required for recombination. In particular, the Rec8 subunit of the meiotic cohesin complex, which is conserved in a wide range of eukaryotes, has been analyzed for its function in modulating chromosomal architecture during the pairing and recombination of homologous chromosomes in meiosis. Here, we review the current understanding of Rec8 cohesin as a structural platform for meiotic chromosomes.

Source: Genes - January 22, 2022 Category: Genetics & Stem Cells Authors: Takeshi Sakuno Yasushi Hiraoka Tags: Review Source Type: research