[TECHNIQUE] Mendelian Randomization: Concepts and Scope
We describe the scope of MR, highlighting the range of applications being made possible as genetic data sets and resources become larger and more freely available. We outline the MR approach in detail, covering concepts, assumptions, and estimation methods. We cover some common misconceptions, provide strategies for overcoming violation of assumptions, and discuss future prospects for extending the clinical applicability, methodological innovations, robustness, and generalizability of MR findings.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Richmond, R. C., Davey Smith, G. Tags: Combining Human Genetics and Causal Inference to Understand Human Disease and Development TECHNIQUE Source Type: research