Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome

Hypertens Pregnancy. 2021 Nov 23:1-8. doi: 10.1080/10641955.2021.2008424. Online ahead of print.ABSTRACTTo evaluate total Th1/Th2 cytokines in CD3+ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3+, INF-g+/CD3+, IL-4+/CD3+, and IL-10+/CD3+, CD4+/CD8+ were determined by flow-cytometry. Preeclampsia (n= 26) and normal pregnancy (n= 25) participants were age and gestational age matched. CD4+ lymphocytes count was higher in preeclampsia, compared with normal pregnancy (43.6 ± 5.8 vs 37.6 ± 5.6%; P< 0.001). CD3+ cells Th1/Th2 shift was not detected in preeclampsia, yet may be present in other cell types, such as CD4+ and CD3 - lymphocytes.PMID:34812111 | DOI:10.1080/10641955.2021.2008424

Source: Hypertension in Pregnancy - November 23, 2021 Category: OBGYN Authors: Iara Dos Santos Fagundes Eduardo Pletsch Brendler Isadora Nunes Erthal Raquel Jaqueline Eder Ribeiro Rafaela Siviero Caron-Lienert Denise Cantarelli Machado Bartira Erc ília Pinheiro da Costa Carlos Eduardo Poli-de-Figueiredo Source Type: research