Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation

Conditions:   Acute Ischemic Stroke;   Acute Renal Injury Interventions:   Drug: Conestat alfa (Ruconest®);   Drug: NaCl 0.9%) Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation;   Pharming Technologies B.V. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractIschemic stroke, with its high morbidity and mortality, is the most common cerebrovascular accident and results in severe neurological deficits. Despite advances in medical and surgical intervention, post-stroke therapies remain scarce, which seriously affects the quality of life of patients. Over the past decades, stem cell transplantation has been recognized as very promising therapy for neurological diseases. Neural stem cell (NSC) transplantation is the optimal choice for ischemic stroke as NSCs inherently reside in the brain and can potentially differentiate into a variety of cell types within the central nerv...
Source: Translational Stroke Research - Category: Neurology Source Type: research
ConclusionsOur findings support the interpretation of a fenestration of the cervical segment of the internal carotid artery as a developmental vascular variant, but also suggest a substantial risk for dissection and ischemic stroke. Even in case of an accidental finding, clinicians should be aware of this. At least in this case, antiplatelet therapy seemed beneficial.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Am Fam Physician. 2022 Jan 1;105(1):99-102.NO ABSTRACTPMID:35029929
Source: American Family Physician - Category: Primary Care Authors: Source Type: research
We examined implications of exposure to PM composed of metalworking fluids (MWF) for stroke mortality in the United Autoworkers-General Motors cohort. Cox proportional hazards models with age as the timescale were used to estimate the association of cumulative straight, soluble, and synthetic MWF exposure with stroke mortality controlling for sex, race, plant, calendar year, and hire year. Among 38,553 autoworkers followed 1941-1995, we identified 114 ischemic stroke deaths and 113 hemorrhagic stroke deaths. Overall stroke mortality risk was increased among workers in the middle exposure category for straight MWF (HR: 1.31...
Source: Am J Epidemiol - Category: Epidemiology Authors: Source Type: research
CONCLUSIONS: Antiplatelet therapy with aspirin 160 mg to 300 mg daily, given orally (or by nasogastric tube or per rectum in people who cannot swallow) and started within 48 hours of onset of presumed ischaemic stroke, significantly decreased death and dependency, and reduced the risk of early recurrent ischaemic stroke without a major risk of early haemorrhagic complications; long-term outcomes were improved.PMID:35028933 | DOI:10.1002/14651858.CD000029.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
J Med Life. 2021 Sep-Oct;14(5):700-709. doi: 10.25122/jml-2021-0362.ABSTRACTThe main aim of this study is to systematically record Cerebrolysin treatment modalities and concomitant medication, according to local standards, in patients with moderate to severe neurological deficits after acute ischemic stroke and to assess the impact of these parameters on therapy outcome during early rehabilitation (day 21) and on day 90. An open observational treatment design based on the principles of high-quality comparative effectiveness research (HQCER) has been chosen to capture the therapies as applied in real-world clinical practice...
Source: Journal of Medicine and Life - Category: General Medicine Authors: Source Type: research
Conclusion: The titration strategy was effective in lowering the incidence of cumulative dipyridamole-induced headache.Cerebrovasc Dis
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
AbstractStroke is the second leading cause of death after coronary heart disease in developed countries and is the greatest cause of disability and cognitive impairment. Risk factors for cognitive impairment and dementia after stroke are multifactorial including older age, family history, hypertension, arterial fibrillation, diabetes, genetic variants, low educational status, vascular comorbidities, prior transient ischaemic attack or recurrent stroke, depressive illness duration of a stroke, location, volume, intensity, and degree of neuronal degeneration, location and size of infarction after stroke, time interval after ...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low A...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsOur study demonstrates that poor CAC was independently associated with the presence of the APCV in patients with ICAO. Severe stroke was independently associated with the APMV.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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