Upadacitinib Delivers Rapid Response in Ulcerative Colitis Upadacitinib Delivers Rapid Response in Ulcerative Colitis

Serious and severe adverse events, as well as higher rates of discontinuation due to treatment-related adverse events, were more common in the placebo group.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Related Links:

Int J Biol Macromol. 2022 Jan 18:S0141-8130(22)00058-7. doi: 10.1016/j.ijbiomac.2022.01.049. Online ahead of print.ABSTRACTChitin derivatives (CDs), including chitosan (CS), chitooligosaccharides (COS), and glucosamine (GlcN), were administrated in dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) mice. UC symptoms such as body weight loss, reduced food intake, and increased disease activity index were relieved (except GlcNL group). CDs (except GlcNL) exerted a strong protective effect on colon length and colonic structure. Treatment with CDs (except GlcNL) increased IL-10 level, reduced levels of IL-1β, IL...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
Eur J Case Rep Intern Med. 2021 Dec 9;8(12):003032. doi: 10.12890/2021_003032. eCollection 2021.ABSTRACTRamsay Hunt syndrome is a rare complication of herpes zoster that results from reactivation of varicella-zoster virus in the geniculate ganglion of the VII cranial nerve. Immunosuppression can lead to reactivation of latent varicella-zoster virus, resulting in herpes zoster. Here, we present a case of Ramsay Hunt syndrome in a patient with ulcerative colitis under treatment with infliximab.LEARNING POINTS: Ramsay Hunt syndrome is a rare form of herpes zoster and characterized by the presence of otalgia, facial palsy, ver...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
Expert Rev Gastroenterol Hepatol. 2022 Jan 21. doi: 10.1080/17474124.2022.2032662. Online ahead of print.ABSTRACTINTRODUCTION: The detection of cytomegalovirus (CMV) in setting of inflammatory bowel disease often creates confusion whether CMV is a 'bystander' or 'disease'.AREAS COVERED: : This review discusses the clinical conundrum of CMV in ulcerative colitis, approach to discriminate infection from disease, and therapeutic considerations (immunosuppressive and anti-CMV treatment). CMV disease should be considered in corticosteroid refractory/ dependent and thiopurine refractory disease. Endoscopy may reveal deep punched...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Chen Incidence of gastrointestinal (GI) cancers is increasing, and late-stage diagnosis makes these cancers difficult to treat. Chronic and low-grade inflammation are recognized risks for most GI cancers. The GI mucosal immune system maintains healthy homeostasis and signalling molecules made from saturated fats, bioactive sphingolipids, play essential roles in healthy GI immunity. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is a key mediator in a balanced GI immune response. Disruption in the S1P pathway underlies systemic chronic metabolic inflammatory disorders, including diabetes and GI cancers, provi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
e Vergnolle Louis Buscail Proctocolectomy with ileal pouch-anal anastomosis is the intervention of choice for ulcerative colitis and familial adenomatous polyposis requiring surgery. One of the long-term complications is pouch cancer, having a poor prognosis. The risk of high-grade dysplasia and cancer in the anal transitional zone and ileal pouch after 20 years is estimated to be 2 to 4.5% and 3 to 10% in ulcerative colitis and familial polyposis, respectively. The risk factors for ulcerative colitis are the presence of pre-operative dysplasia or cancer, disease duration > 10 years and severe villous atrophy....
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Chronic pouchitis and Crohn's disease after Ileal pouch anal anastomosis (IPAA) for ulcerative colitis could be a larger issue than previously reported.
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
We present the first report of real world data describing the use of ozanimod in clinical practice.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
Multiple studies have suggested that combination therapy with thiopurines and anti-TNFs is superior to monotherapy in Crohn's disease (CD) and ulcerative colitis (UC). The optimal dose of thiopurines in combination therapy remains unclear. Our aim was to determine the impact of thiopurine dosing in combination therapy on the formation of anti-TNF antibodies and clinical outcomes in inflammatory bowel disease (IBD).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
We present a young female with ASUC, who was successfully treated with high dose Tofacitinib after Steroids and Infliximab failure.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
Pivotal trials in ulcerative colitis (UC) have indicated that earlier intervention with a biologic is associated with greater likelihood of treatment response. However, in real-world clinical practice, patients with newly diagnosed UC are often prescribed conventional therapies, such as immunomodulators (IM), corticosteroids (CS), and/or 5-aminosalicylates (5-ASA) before biologic treatment, which may result in suboptimal clinical outcomes and high costs. RALEE is an observational study investigating the impact of early versus delayed initiation of vedolizumab (VDZ) on clinical and economic outcomes in patients with inflamm...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
More News: Gastroenterology | Health | Inflammatory Bowel Disease | Ulcerative Colitis