HIV-1 integrase binding to genomic RNA 5 ′-UTR induces local structural changes in vitro and in virio

During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA...

Source: Retrovirology - November 22, 2021 Category: Virology Authors: Shuohui Liu, Pratibha C. Koneru, Wen Li, Chathuri Pathirage, Alan N. Engelman, Mamuka Kvaratskhelia and Karin Musier-Forsyth Tags: Research Source Type: research