Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity

AbstractAplydactylonins A-C (1–3), three new sesquiterpenes, were isolated from the Vietnamese sea hareAplysia dactylomela. Their structures and absolute configurations were elucidated based on spectroscopic analysis, X-ray crystallography, and density functional theory (DFT) calculations of NMR and ECD data. Compound2 exhibited cytotoxicity against HepG2, DU145 and A549 cells with respective IC50 values of 4.08  ± 0.63, 38.64 ± 1.04 and 12.33 ± 0.95 µM. In addition, HepG2 cells treated with 5 μM compound2 for 48  h showed a significant increase in early apoptotic cells (P <  0.05) and increased caspase 3 activity (P <  0.01). Moreover, compound2 induced sub-G1 phase arrest in HepG2 cells.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research