Residues T48 and A49 in HIV-1 NL4-3 Nef are responsible for the counteraction of autophagy initiation, which prevents the ubiquitin-dependent degradation of Gag through autophagosomes

Autophagy plays an important role as a cellular defense mechanism against intracellular pathogens, like viruses. Specifically, autophagy orchestrates the recruitment of specialized cargo, including viral compo...

Source: Retrovirology - October 28, 2021 Category: Virology Authors: Sergio Castro-Gonzalez, Yuexuan Chen, Jared Benjamin, Yuhang Shi and Ruth Serra-Moreno Tags: Research Source Type: research