The Relationship Between Androgen Deprivation Therapy Duration and External Beam Radiotherapy With or Without a Brachytherapy Boost in High-Risk Prostate Cancer

CONCLUSION: A clear relationship between ADT duration and DM risk following definitive radiotherapy in patients with HRPCa was seen, with durations of 18-36 months being associated with the lowest risk of DM. The lack of a significant interaction between ADT duration and treatment type implies this relationship persists even in patients receiving EBRT+BT. However, the magnitude of this benefit may differ, and prospective evidence seems warranted to determine the optimal duration of ADT in patients receiving of EBRT+BT.PMID:34700629 | DOI:10.1016/j.ijrobp.2021.07.186

Source: Ann Oncol - October 27, 2021 Category: Cancer & Oncology Authors: A U Kishan J K Wong G S Merrick P T Tran D J J Demanes B J Stish D J Krauss T Wedde W Lilleby R G Stock E M Horwitz M L Steinberg R D Tendulkar B J Moran J D Tward R Martinez-Monge A Berlin D E Spratt R T Dess T Romero Source Type: research