Astrocytes render memory flexible by releasing D-serine and regulating NMDAR tone in the hippocampus

NMDAR hypofunction has been implicated in several psychiatric disorders with an impairment of cognitive flexibility. However, the molecular mechanism of how NMDAR hypofunction with decreased NMDAR tone causes the impairment of cognitive flexibility has been minimally understood. Furthermore, it has been unclear whether hippocampal astrocytes regulate NMDAR tone and cognitive flexibility.

Source: Biological Psychiatry - October 20, 2021 Category: Psychiatry Authors: Wuhyun Koh, Mijeong Park, Ye Eun Chun, Jaekwang Lee, Hyun Soo Shim, Mingu Gordon Park, Sunpil Kim, Moonsun Sa, Jinhyeong Joo, Hyunji Kang, Soo-Jin Oh, Junsung Woo, Heejung Chun, Seung Eun Lee, Jinpyo Hong, Jiesi Feng, Yulong Li, Hoon Ryu, Jeiwon Cho, C. J Tags: Archival Report Source Type: research