Propranolol inhibits the angiogenic capacity of hemangioma endothelia via blocking beta-adrenoceptor in mast cell

CONCLUSIONS: Propranolol inhibit the proliferation of HemECs and promote their apoptosis and autophagy through acting on both β1 and β2 adrenoceptor in mast cell.IMPACT: Treated with propranolol, β1, and β2 adrenoceptor on human mast cell expression was reduced significantly. After hemangioma endothelial cell treated with the supernatants from propranolol-treated human mast cell, its proliferation was decreased, but apoptosis and autophagy were significantly induced. Propranolol can work well in shRNA-ADRB1 or shRNA-ADRB2 transfected HMC-1s. Mast cells may have a role in the action of propranolol in infantile hemangioma through both β1 and β2 adrenoceptors to inhibit the angiogenic capacity of hemangioma endothelial cells.PMID:34650198 | DOI:10.1038/s41390-021-01683-4

Source: Cell Research - October 15, 2021 Category: Cytology Authors: Ying Ye Huaqing Zhong Limin Dou Wei Song Chenbin Dong Wenmin Lu Kuiran Dong Kai Li Jun Li Lingfeng He Wei Gao Chunmei Xia Liuhui Wang Source Type: research