Anti-PD1 efficacy in metastatic urothelial cancer patients associates with intra-tumoral juxtaposition of T helper-type 1 and CD8+ T-cells

CONCLUSIONS: A decrease in the fraction of circulating PD1+ CD4+ T-cells, and juxtaposition of Th1, CD8+, and myeloid cells was associated with response to anti-PD1 treatment in mUC patients.PMID:34615720 | DOI:10.1158/1078-0432.CCR-20-3319

Source: Clinical Cancer Research - October 7, 2021 Category: Cancer & Oncology Authors: Maud Rijnders Hayri E Balcioglu Debbie G J Robbrecht Astrid A M Oostvogels Rebecca Wijers Maureen J B Aarts Paul Hamberg Geert J L H van Leenders J Alberto Nakauma-Gonz ález Jens Voortman Hans M Westgeest Joost L Boormans Ronald de Wit Martijn Lolkema As Source Type: research