246 Epidermal ablation reduces keratinocyte cancer occurrence by reducing skin mutation burden caused by chronic ultraviolet radiation

Ultra-Violet (UV) radiation from sunlight is the main carcinogen driving keratinocyte cancers of the skin. The accumulation of UV-induced mutations on sun-exposed areas leads to field cancerisation. Knowing the regenerative property of the skin, we investigated if epidermal ablation removes mutations on the epidermis and allows less mutated cells from the deeper part of the skin to repopulate the ablated surface. Patients with history of multiple epidermal cancers were subjected to epidermal ablation on their forearms with three different depths of laser (600nm, 400nm and fractional laser).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research