Research Techniques Made Simple: Studying Circular  RNA in Skin Diseases

Circular RNAs (circRNAs) are a unique class of covalently closed, single-stranded RNAs. High-throughput sequencing has uncovered the abundance and complexity of circRNAs. Changes in levels of circRNAs correlate with diverse disease states, including many skin diseases. CircRNAs can function as microRNA inhibitors, protein interactors, or mRNAs. Although circRNAs do have unique topological features, they share many similarities, including primary sequence, with their linear orthologs, so carefully controlled experiments are required to detect and study them.

Source: Journal of Investigative Dermatology - September 21, 2021 Category: Dermatology Authors: Rong Yang, Richard C. Wang Tags: Research Techniques Made Simple Source Type: research