Single-cell analysis reveals MHCII expressing keratinocytes in pressure ulcers with worse healing outcomes

Pressure ulcer (PU) is a chronic wound often seen in spinal cord injury patients and other bed-bound individuals, particularly in the elderly population. Despite its association with high mortality, the pathophysiology of PU remains poorly understood. Here, we compared single-cell transcriptomic profiles of human epidermal cells from PU wound edges with those from uninjured skin and acute wounds (AWs) in healthy donors. We identified significant shifts in the cell composition and gene expression patterns in PU.

Source: Journal of Investigative Dermatology - September 15, 2021 Category: Dermatology Authors: Dongqing Li, Shangli Cheng, Yu Pei, Pehr Sommar, Jaanika K ärner, Eva K. Herter, Maria A. Toma, Letian Zhang, Kim Pham, Yuen Ting Cheung, Zhuang Liu, Xingqi Chen, Liv Eidsmo, Qiaolin Deng, Ning Xu Landén Tags: Original Article Source Type: research