Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues
NK cell suppression of T cells is a key determinant of viral pathogenesis and vaccine efficacy. This process involves perforin-dependent elimination of activated CD4+ T cells during the first 3 days of infection. Although this mechanism requires cell-cell contact, NK cells and T cells typically reside in different compartments of lymphoid tissues at steady state. Here, we showed that NK cell suppression of T cells is associated with transient accumulation of NK cells within T cell–rich sites of the spleen during lymphocytic choriomeningitis virus infection. The chemokine receptor CXCR3 was required for this relocation and suppression of antiviral T cells. Accordingly, NK cell migration was mediated by type I IFN–dependent promotion of CXCR3 ligand expression. In contrast, adenoviral vectors that weakly induced type I IFN and did not stimulate NK cell inhibition of T cells also did not promote measurable redistribution of NK cells to T cell zones. Exogenous IFN rescued NK cell migration during adenoviral vector immunization. Thus, type I IFN and CXCR3 were critical for properly positioning NK cells to constrain antiviral T cell responses. Development of strategies to curtail migration of NK cells between lymphoid compartments may enhance vaccine-elicited immune responses.
The federal government will open the US to international travelers again if they are fully vaccinated and can prove it. For others, exemptions are limited.Medscape Medical News
A new study in North Carolina shows that offering $25 to people getting their first shot was an important factor, while long odds at a big lottery prize made little difference.Associated Press
Allegheny Health Network said Monday that it would be using primary care offices and hospital vaccine clinics to distribute booster shots, now that the federal government has widened the approvals for the vaccinations. Late last week, the federal government added a booster dose of the Moderna and Johnson&Johnson vaccinations to its approval list, for people 65 and over and others from 18 to 64 who have underlying health conditions. Booster doses had already been approved for people who had the …
Wichita State University is one of the latest in Wichita to announce a new Covid-19 vaccine requirement for all of its employees based on a federal mandate from President Joe Biden. In an email sent to faculty and staff on Friday, WSU announced it will require all employees — including full- and part-time workers, as well as student employees — to be fully vaccinated by Dec. 8, regardless of whether or not they work on campus or remotely. WSU employs about 2,500 employee s. "Vaccination of…
Nov 17, 2021. US. Sponsored by Indiana Rural Health Association
"...it shows that people vaccinated for COVID-19 had lower death rates than those who were not vaccinated, even when COVID deaths were excluded..."WebMD Health News
The vaccine manufacturer released the first data from a phase 2/3 study evaluating immune response and safety in children 6-11 years old.Medscape Medical News
Biden administration outlines requirements as it prepares to ease travel restrictions from November 8
The European Medicines Agency said a booster dose of Moderna’s coronavirus vaccine “can be considered” in people aged 18 and above
Researchers at the North Carolina Department of Health and Human Services found the payments encouraged more low-income and old people to show up at vaccination hubs.