Ultradian Rhythms and Oxidative Stress in Lymph-Node Tissue during Ontogenesis

AbstractAge-related features of the ultradian rhythms of the total protein and albumin content in lymph-node tissue have been studied in intact rats and rats exposed to chronic toxic oxidative stress with a chronobiological approach and biochemical methods. During the experiment, the rhythmic activity of the total protein and the albumin content in lymph nodes were compared during ontogenesis and under chronic exposure to a sulfur-containing natural gas. The revealed oscillations in the studied parameters can be characterized as circahoralian (ultradian) with periods of 20 –40 to 60 min. The obtained data indicate a decrease in the adaptive resistance of lymph nodes and exhaustion of the antioxidant system in aging rats. These results can be of practical value for the development of methods to correct for the negative effects of a toxic oxidative stress during ontog enesis.
Source: Advances in Gerontology - Category: Geriatrics Source Type: research