New monoterpenoids from the stigmas of Crocus sativus

AbstractOne new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins N-P (2 –4), along with nine known compounds were isolated from the dried stigmas ofCrocus sativus. The structures of new compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of1,2, and3 were unambiguously assigned by the comparison of experimental and calculated ECD data. This is the first report of the isolation of4 with the HMG moiety from the genusCrocus. Compounds1 and4 exhibited weak anti-inflammatory activities on inhibiting lipopolysaccharide (LPS)-induced NO production.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research