Prolia (denosumab) vs Zometa (zolendronic acid) for bisphos-refractory (or intolerant) Osteoporosis

Prolia (denosumab) vs Zometa (zolendronic acid) for bisphos-refractory (or intolerant) Osteoporosis: Which do you prefer? Prolia is a q 6mo injection, Zometa a q12month infusion. Patients have to be compliant with both, and it's life-long therapy. Though, I've heard that the consequences of mal-compliance with Prolia are more severe, more prone to fractures if you stop the Prolia. True? Thoughts?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Internal Medicine and IM Subspecialties Source Type: forums