Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2

Bioorg Med Chem. 2021 Jul 23;45:116329. doi: 10.1016/j.bmc.2021.116329. Online ahead of print.ABSTRACTAgrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-d-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.PMID:34329818 | DOI:10.1016/j.bmc.2021.116329

Source: Bioorganic and Medicinal Chemistry - July 30, 2021 Category: Chemistry Authors: Yeong-Geun Lee Kyung Won Kang Woojae Hong Yeon Hwa Kim Jen Taek Oh Dae Won Park Minsung Ko Yun-Feng Bai Young-Jin Seo Sang-Myeong Lee Hyunggun Kim Se Chan Kang Source Type: research