Renal and metabolic effects of SGLT-2i and DPP-4i according to basal estimated glomerular filtration rate: analysis from GIOIA, an observational prospective study
In the GIOIA study, users of both SGLT-2i and DPP-4i improved glycometabolic control, after 12 months, independently from baseline eGFR levels. Moreover, both classes led to a significant decrease in eGFR in participants with eGFR ≥90 ml/min/1.73m2 and no deterioration in case of mild impaired renal function.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Miriam Longo, Lorenzo Scappaticcio, Maria Ida Maiorino, Luca De Nicola, Giuseppe Bellastella, Katherine Esposito Source Type: research