Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

Chem Commun (Camb). 2021 Jul 27. doi: 10.1039/d1cc02930d. Online ahead of print.ABSTRACTThe construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition, they exhibit efficient reactivity in the palladium-catalyzed cross-coupling reaction and orthogonal reactivity with boron reagents, therefore acting as robust nucleophiles for the synthesis of tertiary cyclopropane and efficient intermediates for the formation of quaternary centers.PMID:34318815 | DOI:10.1039/d1cc02930d

Source: Chemical Communications - July 28, 2021 Category: Chemistry Authors: Shuo Yang Wei-Tao Jiang Bin Xiao Source Type: research