< em > TP53 < /em > mutations with low variant allele frequency predict short survival in Chronic Lymphocytic Leukemia

CONCLUSIONS: TP53 mutations impacted OS irrespective of VAF. This finding can be used to update the definition of TP53 mutated CLL for clinical purposes.PMID:34285062 | DOI:10.1158/1078-0432.CCR-21-0701

Source: Clinical Cancer Research - July 21, 2021 Category: Cancer & Oncology Authors: Riccardo Bomben Francesca Maria Rossi Filippo Vit Tamara Bittolo Tiziana D'Agaro Antonella Zucchetto Erika Tissino Federico Pozzo Elena Vendramini Massimo Degan Eva Zaina Ilaria Cattarossi Paola Varaschin Paola Nanni Michele Berton Alessandra Braida Jerry Source Type: research