Method Optimisation in Hydrophilic-Interaction Liquid Chromatography by Design of Experiments Combined with Quantitative Structure & #x2013;Retention Relationships

Maryam Taraji, Paul R. Haddad A quality by design approach combined with quantitative structure–retention relationships and design of experiment principles is used to select the optimal conditions for maximum separation of a set of test analytes for a range of stationary phases in hydrophilic–interaction liquid chromatography. The accuracy of prediction of retention times was in the range 7.6–11.0 %.
Source: Australian Journal of Chemistry - Category: Chemistry Authors: Source Type: research