Transforming growth factor- β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

Exhausted T  cells are heterogenous, consisting of subpopulations with different functional and developmental properties. Gabriel et al. demonstrate that TGF-β-mediated mTOR inhibition preserves the cellular metabolism of precursors of exhausted T cells, which both limits and sustains long-term T cell resp onses in chronic infections.

Source: Immunity - July 6, 2021 Category: Allergy & Immunology Authors: Sarah S. Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-Le ón, Patrick M. Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Wei Shi, Daniel T. Utzschneider, Axel Kallies Tags: Article Source Type: research