Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids

Prostaglandins (PGs) bind to specific G-protein coupled receptors (GPCRs) on target cells, thus initiating a series of intracellular effects. Of the major metabolites of cyclooxygenase (COX) enzymes, PGE2, PGF2 α and PGI2 are the most abundant PGs [1, 2]. Although it is well known that both EP2 and FP receptors are co-expressed in the same cells, both receptors regulate intracellular signaling in different manners. EP2 receptors couple to Gαs, resulting in an increase in cAMP levels, and FP receptors cou ple to Gαq resulting in the release of inositol-1,4,5-triphosphate (IP) and dialcylglycerol (DAG) [2-5].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 3, 2021 Category: Biomedical Science Authors: Yosuke Ida, Megumi Watanabe, Araya Umetsu, Hiroshi Ohguro, Fumihito Hikage Source Type: research