Malondialdehyde-acetaldehyde adduct formation decreases immunoglobulin A transport across airway epithelium in smokers who abuse alcohol

Alcohol misuse and smoking are risk factors for pneumonia, yet the impact of combined cigarette smoke and alcohol on pneumonia remains understudied. Smokers who misuse alcohol form lung malondialdehyde-acetaldehyde (MAA) protein adducts and have decreased levels of anti-MAA secretory IgA (sIgA). Transforming growth factor beta (TGF β) downregulates polymeric Ig receptor (pIgR) on mucosal epithelium, resulting in decreased sIgA transcytosis to the mucosa. It is hypothesized that MAA-adducted lung protein increases TGFβ, preventing expression of epithelial cell pIgR and decreasing sIgA.

Source: American Journal of Pathology - June 26, 2021 Category: Pathology Authors: Todd A. Wyatt, Kristi J. Warren, Tanner J. Wetzel, Troy Suwondo, Gage P. Rensch, Jane M. DeVasure, Deanna D. Mosley, Kusum K. Kharbanda, Geoffrey M. Thiele, Ellen L. Burnham, Kristina L. Bailey, Samantha M. Yeligar Tags: Regular Article Source Type: research