Early-onset stroke and iron-deficiency anaemia in young siblings

Rheumatology key messagesDADA2 has a highly variable phenotype and may present without overt evidence of vascular inflammation.Young-onset stroke and haematological abnormalities, especially in the presence of consanguinity, should alert the clinician to possible DADA2.Anti-TNF therapy has been shown to be effective for preventing ischaemic episodes, while HSCT remains an option for those who fail to respond to anti-TNF therapy.
Source: Rheumatology - Category: Rheumatology Source Type: research