This Month in AJP

Obliterative bronchiolitis lesions caused by bronchiolitis obliterans syndrome (BOS) may lead to organ failure post lung transplant; however, the molecular composition of these lesions is unclear. Using proteomics approach, M üller et al (Am J Pathol, AJPA-D-20-00499) analyzed the protein composition of the lesions in explanted lungs from four end-stage BOS patients. Protein signatures were established for 14 bronchiolitis obliterans lesions. A set of 39 proteins were identified in over 75% of lesions, with every lesion exhibiting some common features and a unique composition of proteins.
Source: American Journal of Pathology - Category: Pathology Tags: This Month in AJP Source Type: research