Microaerobic growth-decoupled production of α-ketoglutarate and succinate from xylose in a one-pot process using Corynebacterium glutamicum

CONCLUSION: The developed one-pot process represents a promising approach for the combined supply of bio-based α-ketoglutarate and succinate. Future work will focus on tailor-made down-stream processing of both organic acids from the fermentation broth to enable their application as building blocks in chemical syntheses. Alternatively, direct conversion of one or both acids via whole-cell or cell-free enzymatic approaches can be envisioned, thus extending the network of value chains starting from cheap and renewable d-xylose. This article is protected by copyright. All rights reserved.PMID:34089621 | DOI:10.1002/biot.202100043

Source: Biotechnology Journal - June 5, 2021 Category: Biotechnology Authors: Niklas Tenhaef Jannick Kappelmann Arabel Eich Marc Weiske Lisette Brie ß Christian Br üsseler Jan Marienhagen Wolfgang Wiechert Stephan Noack Source Type: research