An integrated modular framework for modeling the effect of ammonium on the sialylation process of monoclonal antibodies produced by CHO cells

CONCLUSION: The presented model in this study provides a connection between extracellular ammonium and the monoclonal antibody sialylation process. This computational tool could help scientists to develop and formulate cell culture media. The model illustrated here can assist the researchers to select culture media that ensure consistent mAB sialylation. This article is protected by copyright. All rights reserved.PMID:34021707 | DOI:10.1002/biot.202100019

Source: Biotechnology Journal - May 22, 2021 Category: Biotechnology Authors: Iman Shahidi Pour Savizi Ehsan Motamedian Nathan E Lewis Ioscani Jimenez Del Val Seyed Abbas Shojaosadati Source Type: research