Genes, Vol. 12, Pages 726: Craniofacial Diseases Caused by Defects in Intracellular Trafficking

Genes, Vol. 12, Pages 726: Craniofacial Diseases Caused by Defects in Intracellular Trafficking Genes doi: 10.3390/genes12050726 Authors: Chung-Ling Lu Jinoh Kim Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinations through intracellular trafficking pathways. Some of the signaling molecules play a critical role in craniofacial morphogenesis. Not surprisingly, variants in the genes encoding intracellular trafficking machinery can cause craniofacial diseases. Despite the fundamental importance of the trafficking pathways in craniofacial morphogenesis, relatively less emphasis is placed on this topic, thus far. Here, we describe craniofacial diseases caused by lesions in the intracellular trafficking machinery and possible treatment strategies for such diseases.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
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