Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice

CONCLUSIONS: These data implicate CaSR in CPAP effects on airway function with implications for wheezing in former preterm infants.IMPACT: Neonatal CPAP increases airway reactivity to bronchoconstrictor agonist. CPAP increases smooth muscle expression of the extracellular calcium-sensing receptor (CaSR). Inhibition or absence of CaSR blunts CPAP effects on contractility. These data suggest a causal/contributory role for CaSR in stretch effects on the developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.PMID:33958714 | DOI:10.1038/s41390-021-01540-4

Source: Pediatric Research - May 7, 2021 Category: Pediatrics Authors: Catherine A Mayer Benjamin Roos Jacob Teske Natalya Wells Richard J Martin Wenhan Chang Christina M Pabelick Y S Prakash Peter M MacFarlane Source Type: research