IVF and the exogenous progesterone-free luteal phase

This article summarizes several approaches of the exogenous progesterone-free luteal support in IVF. Recent findings Triggering ovulation with GnRH agonist may serve as an alternative to hCG, with well established advantages. In addition, the luteal phase can be individualized in order to achieve a more physiologic hormonal milieu, and a more patient friendly treatment, alleviating the burden of a lengthy exogenous progesterone therapy. Summary GnRH agonist trigger followed by a ‘freeze all’ policy is undoubtedly the best approach towards the ‘OHSS-free clinic’. If fresh embryo transfer is considered well tolerated after GnRH agonist trigger, rescue of the corpora lutea by LH activity supplementation is mandatory. Herein we discuss the different approaches of corpus luteum rescue.
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. Garcia Velasco Source Type: research