B Cells in Relapsing Lupus Nephritis and Cutaneous Vasculitis B Cells in Relapsing Lupus Nephritis and Cutaneous Vasculitis

A case of a woman with systemic lupus erythematosus whose nephritis and cutaneous vasculitis were refractory to treatment.HSS Grand Rounds Complex Cases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Clinical Case Source Type: news

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Discussion Kidneys are amazing in that they filter the blood, eliminate toxins, balance fluids and electrolytes plus have a lot of reserve to do the job they need to do even when injured. Therefore, depending on the problem, chronic renal disease (CRD) often allows time before renal replacement therapy (RRT) is needed. RRT currently is dialysis (peritoneal or hemodialysis) or renal transplant. In general, the patient’s own kidneys do the best job for them but there is always a balance between the problems of CRD and its management, versus the potentially improved renal function with RRT. RRT itself though has a diffe...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Arthritis Res Ther. 2021 Aug 13;23(1):211. doi: 10.1186/s13075-021-02589-6.ABSTRACTBACKGROUND: Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used for ANCA-associated vasculitis (AAV) and as off-label therapy for systemic lupus erythematosus (SLE), but data on occurrence and predisposing factors to ADAs in these diseases is limited.OBJECTIVES: To elucidate the rate of occurrence, and risk factors for ADAs against rituximab in SLE and AAV.METHODS: A...
Source: Cell Research - Category: Cytology Authors: Source Type: research
ConclusionIn the case of cervical lymphadenopathy in a patient with systemic lupus erythematosus, the possibilities of lupus lymphadenopathy, Kikuchi –Fujimoto disease, and lymphoma should all be considered, after excluding secondary infection due to immunosuppression. Histology confirms the differentiation of these pathologies. It is important to differentiate the cause for lymphadenopathy in systemic lupus erythematosus as the outcome and tre atment varies. Lupus lymphadenopathy is usually generalized, but isolated cervical lymphadenopathy could also rarely be the first presentation of systemic lupus erythematosus....
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Lupus nephritis is a severe organ manifestation in systemic lupus erythematosus leading to kidney failure in a subset of patients. In lupus-prone mice, controlled infection with Plasmodium parasites protects against the progression of autoimmune pathology including lethal glomerulonephritis. Here, we demonstrate that parasite-induced protection was not due to a systemic effect of infection on autoimmunity as previously assumed, but rather to specific alterations in immune cell infiltrates into kidneys and renal draining lymph nodes. Infection of lupus-prone mice with a Plasmodium parasite did not reduce the levels or speci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Ren Fail. 2021 Dec;43(1):851-859. doi: 10.1080/0886022X.2021.1923527.ABSTRACTPURPOSE: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.METHODS: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group, n = 5923) and at least 60 years (elderly group, n = 1199). The clinical and pathological characteristics of renal biopsy patients in th...
Source: Renal Failure - Category: Urology & Nephrology Authors: Source Type: research
Free Radic Biol Med. 2021 Apr 29:S0891-5849(21)00278-1. doi: 10.1016/j.freeradbiomed.2021.04.032. Online ahead of print.ABSTRACTExtracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors that induce vascular inflammation by leukocyte recruitment and thrombosis. Furthermore, vesicles release...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Source Type: research
ConclusionInfections occur frequently with current IS regimens in aggressive glomerulonephritis. Pulmonary involvement and high-dose corticosteroid regimen were the most significant risk factors for infections.Key Points•Infections occur frequently with current immunosuppressive regimens in autoimmune aggressive glomerulonephritis.•High-dose corticosteroids are the major contributors to the risk for serious infections.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
We describe techniques to stain deposits and compare the occurrence of deposits in healthy kidneys and in a wide spectrum of kidney diseases, including hypertensive nephropathy, diabetic nephropathy, membranous nephropathy, IgA nephropathy, lupus nephritis, C3 glomerulopathy, and thrombotic microangiopathies such as the atypical hemolytic uremic syndrome, vasculitis, interstitial nephritis, acute tubular necrosis, kidney tumors, and rejection of kidney transplants. We summarize how these deposits are related with other histological lesions and clinical characteristics. We evaluate the prognostic relevance of these deposits...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionAnti-GBM antibodies were not detected in the serum of Caucasian patients with SLE, even in case of renal involvement, a situation favoring the antigenic exposure of glomerular basement membranes. Our results reaffirm the central role of anti-GBM antibodies as a specific diagnostic biomarker for Goodpasture vasculitis and therefore confirm that anti-GBM antibody must not be carried out in patients with SLE (with or without LN) in the absence of disease-suggestive symptoms.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Nature Reviews Nephrology, Published online: 11 December 2020; doi:10.1038/s41581-020-00388-xIn 2020 a number of clinical trials have provided insights into therapeutic approaches for the treatment of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis and lupus nephritis. Moreover, mechanistic insights have potential to open new therapeutic strategies in the future.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
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