Role of progesterone, cerclage and pessary in preventing preterm birth in twin pregnancies: a systematic review and network meta-analysis

Twin pregnancies are at increased risk of perinatal mortality and morbidity compared to singleton, mainly as the results of fetal anomalies, growth disorders and preterm birth (PTB)1,2. PTB is the major determinant of adverse perinatal outcome in twin pregnancies, with an estimated incidence of 59% and 11% before 37 and 32 weeks of gestation, respectively1. The large majority of PTB in twins is spontaneous, following either preterm premature rupture of membranes (PROM) or spontaneous onset of labor, although a significant proportion of these pregnancies are delivered preterm after iatrogenic obstetrical interventions for maternal-fetal indications1.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research