Clinical Effects of Balanced Crystalloids vs Saline in Adults with Diabetic Ketoacidosis

Intravenous fluid (IVF) administration is a key component in the treatment of diabetic ketoacidosis (DKA). Normal saline is currently the primary fluid recommended by clinical practice guidelines for the treatment of DKA; however, it has been shown to cause a hyperchloremic metabolic acidosis due to its high chloride concentration when compared to human plasma. Balanced crystalloid solutions, like Lactated Ringer ’s (LR) and Plasma-Lyte A (Baxter Inc), do not cause a metabolic acidosis as their chloride concentrations are similar to human plasma.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Abstracts Source Type: research