FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Here, we investigated the role of the transcription factor FOSL1, as well as its downstream transcriptional effectors, in the development and progression of CCA.

Source: Journal of Hepatology - April 19, 2021 Category: Gastroenterology Authors: Adri án Vallejo, Oihane Erice, Rodrigo Entrialgo-Cadierno, Iker Feliu, Elizabeth Guruceaga, Maria J. Perugorria, Paula Olaizola, Alexandra Muggli, Irati Macaya, Michael O’Dell, Borja Ruiz-Fernandez de Cordoba, Sergio Ortiz-Espinosa, Aram F. Hezel, Iman Source Type: research