Multisystem Inflammation and Susceptibility to Viral infections in Human ZNFX1 Deficiency

The recognition of viral nucleic acids is one of the primary triggers for a type I interferon-mediated antiviral immune response. Inborn errors of type I interferon immunity can be associated with increased inflammation and/or increased susceptibility to viral infections, as a result of dysbalanced interferon production. NFX1-type zinc-finger-containing 1 (ZNFX1) is an interferon-stimulated double-strand RNA sensor that restricts the replication of RNA viruses in mice. ZNFX1 ’s role in the human immune response is not known.

Source: Journal of Allergy and Clinical Immunology - April 16, 2021 Category: Allergy & Immunology Authors: Stefano Vavassori, Janet Chou, Laura Eva Faletti, Veronika Haunerdinger, Lennart Opitz, Pascal Joset, Christopher J. Fraser, Seraina Prader, Xianfei Gao, Luise A. Schuch, Matias Wagner, Julia Hoefele, Maria Elena Maccari, Ying Zhu, George Elakis, Michael Source Type: research