Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia

Individuals with H αT have increased numbers of activated mast cells in the small intestine, accelerated intestinal epithelial cell pyroptosis, expanded class-switched memory B cells, and increased GI-associated antigen-directed antibody production.

Source: Journal of Allergy and Clinical Immunology - April 15, 2021 Category: Allergy & Immunology Authors: Liza Konnikova, Tanya O. Robinson, Anna H. Owings, James F. Shirley, Elisabeth Davis, Ying Tang, Sarah Wall, Jian Li, Mohammad H. Hasan, Raad Z. Gharaibeh, Lybil B. Mendoza Alvarez, Lisa K. Ryan, Andria Doty, Jack F. Chovanec, Michael P. O ’Connell, Dia Source Type: research