Kinetics of postoperative drain fluid amylase values after pancreatoduodenectomy: New insights to dynamic, data-driven drain management

Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most dreadful complication after pancreatoduodenectomy (PD).1 Postoperative day 1 (POD1) drain fluid amylase (DFA) is a well-established, initial, objective predictor of CR-POPF after surgery, and multiple cutoffs (range:100 –5,000 U/L) have been proposed as outright, seemingly absolute, parameters to inform subsequent drain management.2–5 However, conceptually the appropriateness of dichotomous, yet static POD1 DFA thresholds can be questioned.

Source: Surgery - April 9, 2021 Category: Surgery Authors: Amer H. Zureikat, Fabio Casciani, Sarwat Ahmad, Claudio Bassi, Charles M. Vollmer Source Type: research