Evolution of the gross tumour volume extent during radiotherapy for glioblastomas

Despite aggressive treatment consisting of maximal surgical debulking followed by radiotherapy (RT), and concomitant and adjuvant temozolomide (TMZ) [1], the prognosis for glioblastoma multiforme (GBM) patients remains poor with 2 years survival rate around 26% [2,3]. Since the late 1970s, RT has been part of standard treatment for patients with GBMs. Initially, whole-brain irradiation was applied, but the morbidity related to this treatment and the documentation of treatment failures primarily being local recurrences introduced regional radiation fields [4].

Source: Radiotherapy and Oncology - April 9, 2021 Category: Radiology Authors: Uffe Bernchou, Trine Skak Tranemose Arnold, Brit Axelsen, Mette Kl üver-Kristensen, Faisal Mahmood, Frederik Severin Gråe Harbo, Jon Thor Asmussen, Olfred Hansen, Anders Smedegaard Bertelsen, Steinbjørn Hansen, Carsten Brink, Rikke Hedegaard Dahlrot Tags: Original Article Source Type: research