Sex differences in noradrenergic modulation of attention and impulsivity in rats

ConclusionsAtomoxetine showed significant improvement in impulsivity, but atomoxetine had less beneficial effects on impulsive control in females than in males, and it even impaired attentional performance in female rats. The α1 receptors were mainly responsible for NE drug-related sex differences in attention rather than impulsivity. The results obtained in this study indicate that the sex differences exist in both attention and impulsivity by the modulation of noradrenaline and raise the concern to improve sex-specifi c treatments.
Source: Psychopharmacology - Category: Psychiatry Source Type: research